Abstract:
:RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-kappaB pathway. Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IkappaB by upstream kinases. However, contrary to what one would expect of a scaffold protein, our results show that RKIP has an overall inhibitory effect on the NF-kappaB transcriptional activities. Since NF-kappaB target gene expression is subject to negative regulation involving the optimal induction of negative regulators, our data support a hypothesis that RKIP inhibits NF-kappaB activity via the auto-regulatory feedback loop by rapidly inducing the expression and synthesis of inhibitors of NF-kappaB activation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tang H,Park S,Sun SC,Trumbly R,Ren G,Tsung E,Yeung KCdoi
10.1016/j.febslet.2009.12.051subject
Has Abstractpub_date
2010-02-19 00:00:00pages
662-8issue
4eissn
0014-5793issn
1873-3468pii
S0014-5793(09)01097-7journal_volume
584pub_type
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