Abstract:
:The homeodomain protein, Cdx2, has been implicated in the transcriptional regulation of genes expressed in the small intestine. In vitro studies of the carbonic anhydrase 1 (CA1) colon promoter implied that Cdx2 may also play a role in the regulation of colon-specific gene expression. The current work follows up this proposal by examining the ability of Cdx2 to transactivate gene expression in cultured cells mediated by CA1 promoter sequences. The results show that Cdx2 exerts a positive regulatory effect by binding to a motif 87 bp upstream of the CA1 TATA box; this motif appears to act as an enhancer since gene activation is independent of its orientation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Drummond FJ,Sowden J,Morrison K,Edwards YHdoi
10.1016/s0014-5793(98)00103-3subject
Has Abstractpub_date
1998-02-20 00:00:00pages
218-22issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00103-3journal_volume
423pub_type
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