Abstract:
:Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mice are treated with GPX inhibitor for 3 days, pregnancy rate is significantly reduced. Progesterone stimulates Gpx3 expression through PR/HIF1α in mouse endometrial stromal cells. In the decidua, the high level of GPX3 expression is closely associated with the reduction of hydrogen peroxide (H2O2). Based on our data, GPX3 may play a major role in reducing H2O2 during decidualization.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Xu X,Leng JY,Gao F,Zhao ZA,Deng WB,Liang XH,Zhang YJ,Zhang ZR,Li M,Sha AG,Yang ZMdoi
10.1016/j.febslet.2014.02.043subject
Has Abstractpub_date
2014-05-02 00:00:00pages
1580-9issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00163-Xjournal_volume
588pub_type
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