Abstract:
:Gene duplication provides genetic material required for functional diversification. An interesting example is the amyloid precursor protein (APP) protein family. The APP gene family has experienced both expansion and contraction during evolution. The three mammalian members have been studied quite extensively in combined knock out models. The underlying assumption is that APP, amyloid precursor like protein 1 and 2 (APLP1, APLP2) are functionally redundant. This assumption is primarily supported by the similarities in biochemical processing of APP and APLPs and on the fact that the different APP genes appear to genetically interact at the level of the phenotype in combined knockout mice. However, unique features in each member of the APP family possibly contribute to specification of their function. In the current review, we discuss the evolution and the biology of the APP protein family with special attention to the distinct properties of each homologue. We propose that the functions of APP, APLP1 and APLP2 have diverged after duplication to contribute distinctly to different neuronal events. Our analysis reveals that APLP2 is significantly diverged from APP and APLP1.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Shariati SA,De Strooper Bdoi
10.1016/j.febslet.2013.05.026subject
Has Abstractpub_date
2013-06-27 00:00:00pages
2036-45issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00380-3journal_volume
587pub_type
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