Abstract:
:Polysulfide is a bound sulfur species derived from endogenous H2S. When mouse neuroblastoma, Neuro2A cells were exposed to tert-butyl hydroperoxide after treatment with polysulfide, a significant decline in cell toxicity was observed. Rapid uptake of polysulfides induced translocation of Nrf2 into the nucleus, resulting in acceleration of GSH synthesis and HO-1 expression. We demonstrated that polysulfide reversibly modified Keap1 to form oxidized dimers and induced the translocation of Nrf2. Moreover, polysulfide treatment accelerated Akt phosphorylation, which is a known pathway of Nrf2 phosphorylation. Thus, polysulfide may mediate the activation of Nrf2 signaling, thereby exerting protective effects against oxidative damage in Neuro2A cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Koike S,Ogasawara Y,Shibuya N,Kimura H,Ishii Kdoi
10.1016/j.febslet.2013.09.013subject
Has Abstractpub_date
2013-11-01 00:00:00pages
3548-55issue
21eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00698-4journal_volume
587pub_type
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