Abstract:
:The fungal metabolite brefeldin A (BFA) is known to disrupt the Golgi apparatus resulting in redistribution of Golgi proteins to the endoplasmic reticulum and inhibition of protein secretion. BFA was found to inhibit protein synthesis in rat glioma C6 cells by up to 70% between 0.1 and 1 microgram/ml. Inhibition was both time-dependent and reversible. BFA inhibited protein synthesis to varying degrees in a number of other cell lines but not in BFA-resistant marsupial kidney cells. The same concentrations of BFA which inhibited protein synthesis, also blocked the inhibitory effects of Pseudomonas exotoxin and ricin on BFA-sensitive cells. BFA, however, was unable to block the inhibition of protein synthesis by the toxins in the resistant marsupial kidney cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fishman PH,Curran PKdoi
10.1016/0014-5793(92)81508-jkeywords:
subject
Has Abstractpub_date
1992-12-21 00:00:00pages
371-4issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(92)81508-Jjournal_volume
314pub_type
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