Abstract:
:Polyphosphates (polyP) are long chains of inorganic phosphates that can be attached to lysine residues of target proteins as a nonenzymatic post-translational modification. This modification, termed polyphosphorylation, may be particularly prevalent in bacterial and fungal species that synthesize large quantities of polyP. In this study, we evaluated the polyphosphorylation status of over 200 candidate targets in Saccharomyces cerevisiae. We report eight new polyphosphorylated proteins that interact genetically and physically with previous targets implicated in ribosome biogenesis. The expanded target network includes vacuolar proteins Prb1 and Apl5, whose modification with polyP suggests a model for feedback regulation of polyP synthesis, while raising questions regarding the location of polyphosphorylation in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
McCarthy L,Bentley-DeSousa A,Denoncourt A,Tseng YC,Gabriel M,Downey Mdoi
10.1002/1873-3468.13588subject
Has Abstractpub_date
2020-01-01 00:00:00pages
21-30issue
1eissn
0014-5793issn
1873-3468journal_volume
594pub_type
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