Abstract:
:The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cheng SX,Lightfoot YL,Yang T,Zadeh M,Tang L,Sahay B,Wang GP,Owen JL,Mohamadzadeh Mdoi
10.1016/j.febslet.2014.05.007subject
Has Abstractpub_date
2014-11-17 00:00:00pages
4158-66issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00368-8journal_volume
588pub_type
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