Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.

Abstract:

:The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Cheng SX,Lightfoot YL,Yang T,Zadeh M,Tang L,Sahay B,Wang GP,Owen JL,Mohamadzadeh M

doi

10.1016/j.febslet.2014.05.007

subject

Has Abstract

pub_date

2014-11-17 00:00:00

pages

4158-66

issue

22

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(14)00368-8

journal_volume

588

pub_type

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