Abstract:
:Horseradish peroxidase in the presence of hydrogen peroxide (HRP/H2O2) oxidizes a carcinogenic non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) to the ultimate carcinogen, which binds to calf thymus DNA. The principal product of Sudan I oxidation by the HRP/H2O2 system is the benzenediazonium ion. Minor products are hydroxy derivatives of Sudan I, in which the aromatic rings are hydroxylated. The principal oxidative product (the benzenediazonium ion) is responsible for the carcinogenicity of Sudan I, because this ion, formed from this azo dye, binds to DNA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Stiborová M,Asfaw B,Anzenbacher Pdoi
10.1016/0014-5793(88)80776-2subject
Has Abstractpub_date
1988-05-23 00:00:00pages
387-90issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(88)80776-2journal_volume
232pub_type
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