MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells.

Abstract:

:In our study, transcriptome microarrays are used to identify differentially expressed miRNAs and mRNAs in cervical cancer specimens. We find that microRNA-145 (miR-145) expression is significantly decreased in cervical cancer tissues and cell lines, and is associated with advanced cancer stages, large tumor size and moderate/poor differentiation. We show that miR-145 targets the DNA damage repair-associated gene Helicase-like transcription factor (HLTF), which is involved in radio-resistance. Moreover, miR-145 over-expression in cervical cancer cells enhances radiosensitivity in vitro and in vivo. These results indicate that targeting miR-145 may be a novel radiosensitizing strategy for cervical cancer.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Ye C,Sun NX,Ma Y,Zhao Q,Zhang Q,Xu C,Wang SB,Sun SH,Wang F,Li W

doi

10.1016/j.febslet.2015.01.037

subject

Has Abstract

pub_date

2015-03-12 00:00:00

pages

702-9

issue

6

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(15)00066-6

journal_volume

589

pub_type

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