Abstract:
:Insulin-degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus (DM2) and Alzheimer's disease (AD). Here we provide genetic evidence that Drosophila Ide (dIde) antagonizes the insulin signaling pathway and human Abeta-induced neurotoxicity in Drosophila. In this study, we also generated a dIde knockout mutant (dIde(KO)) by gene targeting, and found that loss of IDE increases the content of the major insect blood sugar, trehalose, thus suggesting a conserved role of IDE in sugar metabolism. Using dIde(KO) as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tsuda M,Kobayashi T,Matsuo T,Aigaki Tdoi
10.1016/j.febslet.2010.05.010subject
Has Abstractpub_date
2010-07-02 00:00:00pages
2916-20issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00403-5journal_volume
584pub_type
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