Calcium mobilization by angiotensin II and neurotransmitter receptors expressed in Xenopus laevis oocytes.

Abstract:

:Specific receptors for angiotensin II (AII) were expressed in albino Xenopus laevis oocytes co-injected with poly(A)+ mRNA isolated from rat adrenal cortex and the calcium-specific photoprotein, aequorin. In such oocytes, AII elicited rapid, dose-dependent rises in cytosolic free calcium with light emission responses up to 100-fold above basal levels. Ligand-induced light emission was also observed in oocytes injected with rat brain mRNA and stimulated with acetylcholine and glutamate. These findings demonstrate that mammalian AII receptors expressed in Xenopus oocytes are functionally linked to intracellular Ca2+ mobilization, and indicate the potential value of aequorin-injected oocytes for rapid and specific screening of mRNAs transcribed from expression libraries containing cloned receptor cDNAs.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Sandberg K,Markwick AJ,Trinh DP,Catt KJ

doi

10.1016/0014-5793(88)81055-x

subject

Has Abstract

pub_date

1988-12-05 00:00:00

pages

177-80

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(88)81055-X

journal_volume

241

pub_type

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