Abstract:
:The critical urea concentration (C3*) which destabilizes the structure of bovine serum albumin and chymotrypsinogen was determined by UV difference spectroscopy. The increase of the relative content of mobile rotating water molecules in aqueous urea was formerly shown by millimeter spectroscopy [1]. The rise of rotator content at a urea concentration C3 > or = C3* when the bulk water is practically exhausted is suggested as a main driving force of protein unfolding.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Khurgin Yu,Maksareva Edoi
10.1016/0014-5793(93)81152-psubject
Has Abstractpub_date
1993-01-04 00:00:00pages
149-52issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(93)81152-Pjournal_volume
315pub_type
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