Dual role of tropomyosin on chemically modified actin filaments from skeletal muscle.

Abstract:

:Actin filaments copolymerized with both intact and chemically modified actin monomers restored their sliding activity when they were supplemented with tropomyosin extracted from skeletal muscle. In contrast, the ATPase activation of the copolymers was decreased when supplemented with tropomyosin. The results indicate that tropomyosin along with actin monomers may facilitate sliding activity of the entire actin filament but suppress ATPase activation of intact actin monomers themselves. Accordingly, tropomyosin molecules could be viewed as playing a dual role of both mechanical and chemical regulation of actin monomers.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Honda H,Kitano Y,Hatori K,Matsuno K

doi

10.1016/0014-5793(96)00218-9

subject

Has Abstract

pub_date

1996-03-25 00:00:00

pages

55-8

issue

1-2

eissn

0014-5793

issn

1873-3468

journal_volume

383

pub_type

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