Abstract:
:The increase of hepatic apolipoprotein B (apoB) mRNA editing during rat development was not affected by hypothyroidism. Furthermore, the addition of 3,3',5'-triiodothyronine (T3) to cultured hepatocytes taken from fetal, neonatal and adult rats had no effect on apoB mRNA editing. In contrast, dexamethasone markedly stimulated apoB mRNA editing in hepatocytes taken from neonates. This effect was enhanced by the addition of insulin. For the first time our data provide evidence that glucocorticoids together with insulin are important for the regulation of apoB mRNA editing during postnatal development, whereas thyroid hormones are not critical for this process.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lorentz A,Plonné D,Schulze HP,Dargel Rdoi
10.1016/0014-5793(96)00706-5subject
Has Abstractpub_date
1996-08-05 00:00:00pages
57-60issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(96)00706-5journal_volume
391pub_type
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