Abstract:
:Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addition, CR simultaneously increased the level of SIRT1, a mammalian sirtuin. In HEK293T cells, sirtuin inhibitors decreased the WRN level, and this effect was suppressed by proteasomal inhibitors. Furthermore, we found a decrease in the WRN level in Sirt1-deficient mice. These results indicate that sirtuin-mediated deacetylation stabilizes WRN. STRUCTURED SUMMARY:
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kahyo T,Mostoslavsky R,Goto M,Setou Mdoi
10.1016/j.febslet.2008.06.031subject
Has Abstractpub_date
2008-07-23 00:00:00pages
2479-83issue
17eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00542-5journal_volume
582pub_type
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