Abstract:
:This review focuses on the factors that regulate the proliferation of pancreatic islet beta-cells in vitro, and in particular on the intracellular pathways that convey the mitogenic signal into a proliferative response. Substances as diverse as nutrients, polypeptides, cytokines, adrenergic agents, lithium, phorbol esters and cyclic AMP analogs are all able to stimulate or inhibit beta-cell proliferation in a time- and concentration-dependent manner. The evidence for involvement of cyclic AMP, cyclic GMP, protein kinase C, inositol polyphosphates, GTP-binding proteins, polyamines and oncogenes is reviewed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sjöholm Adoi
10.1016/0014-5793(92)81373-tkeywords:
subject
Has Abstractpub_date
1992-10-19 00:00:00pages
85-90issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(92)81373-Tjournal_volume
311pub_type
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