Transfection of cells with basic fibroblast growth factor and Kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor.

abstract：:A stabilization of both the precursor and the mature beta 1 integrin subunit was observed in metabolically labeled human skin fibroblasts and Molt-4 T lymphocytes upon addition of protein synthesis inhibitors or by ATP depletion. Differential effects of protein synthesis inhibitors are reported since the slow degradat...

journal_title：FEBS letters

authors： Vekeman S,Jaspers M,Cassiman JJ

更新日期：1993-07-26 00:00:00

abstract：:MRL mice bearing the lpr (Fas) or gld (Fas ligand) mutation, MRL-Fas(lpr) or MRL-FasL(gld), respectively, develop arthritis similar to rheumatoid arthritis, but C3H and C57BL/6 mice bearing such mutations do not. In MRL-Fas(lpr) mice, agalactosylated oligosaccharides in serum IgG increase significantly in comparison t...

journal_title：FEBS letters

authors： Kuroda Y,Nakata M,Nose M,Kojima N,Mizuochi T

更新日期：2001-10-26 00:00:00

abstract：:Only one copy of the cell adhesion molecule L1 gene is present in the mouse genome, and only one mRNA of 6 kilobases (kb) is expressed in mouse brain [1987, Neurosci. Lett. 82, 89-94]. We have constructed 5 synthetic oligonucleotide probes covering different parts of the published mouse L1 cDNA sequence. Using these p...

journal_title：FEBS letters

authors： Gaardsvoll H,Andersson AM,Bock E

更新日期：1991-12-02 00:00:00

abstract：:The mixed lineage kinase (MLK) family is a recently described protein kinase family. The MLKs contain a kinase domain followed by a dual leucine zipper-like motif. We previously reported the molecular cloning of LZK (leucine zipper-bearing kinase), a novel MLK, and that LZK activated the c-Jun NH2 terminal kinase (JNK...

journal_title：FEBS letters

authors： Ikeda A,Masaki M,Kozutsumi Y,Oka S,Kawasaki T

更新日期：2001-01-19 00:00:00

abstract：:The requirement of divalent cations for binding of the 46 kDa mannose 6-phosphate receptors to phosphomannan and pentamannose 6-phosphate-substituted bovine serum albumin was examined. Receptors from human liver and human brain bound to both affinity ligands in the absence or presence of divalent cations with similar ...

journal_title：FEBS letters

authors： Junghans U,Waheed A,von Figura K

更新日期：1988-09-12 00:00:00

abstract：:We investigated in vitro effects of recombinant human thrombopoietin (TPO), or c-Mpl ligand, on human platelets. TPO induced rapid dose-dependent tyrosine phosphorylation of several proteins. We identified Janus tyrosine kinases, Tyk2 and JAK2, and a member of STAT (signal transducers and activators of transcription) ...

journal_title：FEBS letters

authors： Ezumi Y,Takayama H,Okuma M

更新日期：1995-10-23 00:00:00

abstract：:Using crude membrane preparations of Saccharomyces cerevisiae, we have demonstrated that glucose and glucose analogues which are not efficiently phosphorylated activate the guanine nucleotide-dependent adenylate cyclase in vitro. The activation appears to be mediated by the Ras proteins. Moreover, data are presented i...

journal_title：FEBS letters

authors： Pardo LA,Sánchez LM,Lazo PS,Ramos S

更新日期：1991-09-23 00:00:00

abstract：:The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modifier proteins, Murine double minute (Mdm2) and Small Ubqui...

journal_title：FEBS letters

authors： Gowran A,Murphy CE,Campbell VA

更新日期：2009-11-03 00:00:00

abstract：:The major mono- and disialogangliosides of the extensively characterized established human glioma line D54MG were isolated and purified from subcutaneous solid xenografts grown in athymic (nu/nu) mice. Structural determination showed that they belonged to the lactotetraosylceramide series. The sialyllactotetraosylcera...

journal_title：FEBS letters

authors： Månsson JE,Fredman P,Bigner DD,Molin K,Rosengren B,Friedman HS,Svennerholm L

更新日期：1986-05-26 00:00:00

abstract：:Eucaryotic DNA is punctuated by many A+T-rich segments that we named A+T-rich linkers. Two types of these A+T-rich linkers can be distinguished: (i) isolated A+T-rich linkers, and (ii) A+T-rich linkers crowded in clusters. We have analysed the distribution of A+T-rich linker across the alpha- and beta-globin gene doma...

journal_title：FEBS letters

authors： Moreau J,Scherrer K

更新日期：1987-08-31 00:00:00

abstract：:HslVU is an ATP-dependent protease consisting of two multimeric components, the HslU ATPase and the HslV peptidase. To gain an insight into the role of HslVU in regulation of cell division, the reconstituted enzyme was incubated with SulA, an inhibitor of cell division in Escherichia coli, or its fusion protein with m...

journal_title：FEBS letters

authors： Seong IS,Oh JY,Yoo SJ,Seol JH,Chung CH

更新日期：1999-07-30 00:00:00

abstract：:Phosphorylation of histone variant H2AX at serine 139, named gammaH2AX, has been widely used as a sensitive marker for DNA double-strand breaks (DSBs). gammaH2AX is required for the accumulation of many DNA damage response (DDR) proteins at DSBs. Thus it is believed to be the principal signaling protein involved in DD...

journal_title：FEBS letters

authors： Yuan J,Adamski R,Chen J

更新日期：2010-09-10 00:00:00

abstract：:An essential difference between eukaryotic ferritins and bacterioferritins is that the latter contain naturally, in vivo haem as Fe-protoporphyrin IX. This haem is located in a hydrophobic pocket along the 2-fold symmetry axes and is liganded by two Met 52. However, in in vivo studies, a cofactor has been isolated in ...

journal_title：FEBS letters

authors： de Val N,Herschbach H,Potier N,Dorsselaer AV,Crichton RR

更新日期：2006-11-13 00:00:00

abstract：:The article presents the results of the first regular study of Russian populations by sequencing the control region of mitochondrial DNA (mtDNA). The sequenced region is the most variable on mtDNA molecule and is commonly used for population and evolutionary studies. Russians form one of the largest ethnic groups (mor...

journal_title：FEBS letters

authors： Orekhov V,Poltoraus A,Zhivotovsky LA,Spitsyn V,Ivanov P,Yankovsky N

更新日期：1999-02-19 00:00:00

abstract：:The main immunogenic region (MIR) of the acetylcholine receptor (AChR) is the target for the majority of high-affinity autoantibodies produced in myasthenia gravis patients. Some monoclonal antibodies (mAbs) to the MIR bind specifically, but with low affinity, to synthetic AChR alpha subunit peptides with the sequence...

journal_title：FEBS letters

authors： Saedi MS,Anand R,Conroy WG,Lindstrom J

更新日期：1990-07-02 00:00:00

abstract：:In blood-borne metastasis, intravasated metastatic tumor cells are thought to localize at the target site via a series of processes involving platelet aggregation, adhesion to endothelium, and invasion through the basal membrane. In the present study, we examined how platelet aggregation contributes to the trafficking...

journal_title：FEBS letters

authors： Koike C,Watanabe M,Isoai A,Kumagai H,Tsukada H,Irimura T,Okada S,Oku N

更新日期：1998-05-08 00:00:00

abstract：:In this study, we demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53. The rapid increase of ROS level was involved in the me...

journal_title：FEBS letters

authors： Liu Z,Ng EK,Liang NC,Deng YF,Leung BC,Chen GG

更新日期：2005-02-28 00:00:00

abstract：:Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors ar...

journal_title：FEBS letters

authors： Chung H,Multhaupt HA,Oh ES,Couchman JR

更新日期：2016-08-01 00:00:00

abstract：:Micromolar concentrations of arachidonic acid cause in Ca2+ loaded heart mitochondria matrix swelling and Ca2+ release. These effects appear to be unrelated to the classical membrane permeability transition (MPT), as they are CsA insensitive, membrane potential independent and can also be activated by Sr2+. Atractylos...

journal_title：FEBS letters

authors： Di Paola M,Zaccagnino P,Oliveros-Celis C,Lorusso M

更新日期：2006-02-06 00:00:00

abstract：:The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1...

journal_title：FEBS letters

authors： Sachinidis A,Weisser P,Ko Y,Schulte K,Meyer zu Brickwedde K,Neyses L,Vetter H

更新日期：1992-11-23 00:00:00

abstract：:The isolation of a brain peptide identical to the intestinal peptide PHI (peptide HI) is described. The peptide was isolated from porcine brain extract using a chemical assay method based on its C-terminal isoleucine amide structure. The complete amino acid sequence of the peptide was found to be: His-Ala-Asp-Gly-Val-...

journal_title：FEBS letters

authors： Tatemoto K,Carlquist M,McDonald TJ,Mutt V

更新日期：1983-03-21 00:00:00

abstract：:The 14 kDa protein was purified from human platelets. It displays high cytotoxic activity to the human ACL cells at 10 M concentration (21.8+/-7.1%). Its N-terminal sequence is YAPQXQFGP-, being highly homologous to region 241-249 residues of the human Cls complement component. ...

journal_title：FEBS letters

authors： Golubeva TS,Paromov VM,Tuguz AR,Chertov OY,Kiselevsky MV

更新日期：1997-04-01 00:00:00

abstract：:We used site-directed mutagenesis to modify the Bacillus thuringiensis cry3A gene in amino acid residues 350-354. Two mutant toxins, A1 (R(345)A,Y(350)F,Y(351)F) and A2 (R(345)A,DeltaY(350), DeltaY(351)), showed significantly improved toxicity against Tenebrio molitor (yellow mealworm). The mutant toxin A1 was also mo...

journal_title：FEBS letters

authors： Wu SJ,Koller CN,Miller DL,Bauer LS,Dean DH

更新日期：2000-05-12 00:00:00

abstract：:VP64 is widely used as a transcriptional activator to investigate the biological function of genes, but its potential for application in genetic improvement of crops has not been fully investigated. Here, we characterized an OsMYB1R1-VP64 fusion protein that enhanced the grain yield of rice cultivar 'Kita-ake' by 35%....

journal_title：FEBS letters

authors： Wang J,Wu F,Zhu S,Xu Y,Cheng Z,Wang J,Li C,Sheng P,Zhang H,Cai M,Guo X,Zhang X,Wang C,Wan J

更新日期：2016-10-01 00:00:00

abstract：:Two-dimensional crystalline arrays of annexin IV were generated by interaction of the purified protein with a phospholipid monolayer. Image analysis of electron micrographs of the protein crystals, which diffracted to 3.5 nm respectively, revealed p6 and p3 symmetry. Annexin IV gave two crystal forms with unit cells o...

journal_title：FEBS letters

authors： Newman RH,Leonard K,Crumpton MJ

更新日期：1991-02-11 00:00:00

abstract：:Monoclonal antibodies (mAbs) against cell surface antigens and receptors are instrumental in defining specific membrane markers. mAbs GF 26.7.3 and MF 25.1 against human neutrophils modulated the activation mechanism of superoxide anion production induced by formyl-peptide and PMA in all subject. However, treatment wi...

journal_title：FEBS letters

authors： Traniello S,Spisani S,Gavioli R,Dovigo L,Baricordi RO,Sensi A,Damiani G

更新日期：1986-08-11 00:00:00

abstract：:The hepatocyte growth factor/scatter factor (HGF/SF) receptor consists of an alpha- and a beta-subunit, which are derived from a single-chain precursor by endoproteolytic processing. The precursor is not proteolytically processed in LoVo colon carcinoma cells. The uncleaved receptor immunopurified from the cells was c...

journal_title：FEBS letters

authors： Komada M,Hatsuzawa K,Shibamoto S,Ito F,Nakayama K,Kitamura N

更新日期：1993-08-09 00:00:00

abstract：:Human parainfluenza virus type 3 (hPIV3) recognizes both α2,3- and α2,6-linked sialic acids, whereas human parainfluenza virus type 1 (hPIV1) recognizes only α2,3-linked sialic acids. To identify amino acid residues that confer α2,6-linked sialic acid recognition of hPIV3, amino acid residues in or neighboring the sia...

journal_title：FEBS letters

authors： Fukushima K,Takahashi T,Ueyama H,Takaguchi M,Ito S,Oishi K,Minami A,Ishitsubo E,Tokiwa H,Takimoto T,Suzuki T

更新日期：2015-05-08 00:00:00

abstract：:In Drosophila, the tumor suppressor Scribble is localized at the septate junctions of epithelial cells. Its mammalian homologue, hScrib, is a basolateral protein likely associated to proteins of the cell-cell junctions. We report the direct interaction between hScrib and ZO-2, a junction-associated protein. This inter...

journal_title：FEBS letters

authors： Métais JY,Navarro C,Santoni MJ,Audebert S,Borg JP

更新日期：2005-07-04 00:00:00

abstract：:Mitochondria of amoeba Acanthamoeba castellanii, a non-photosynthetic soil amoeboid protozoon, possess an uncoupling protein (AcUCP) that mediates free fatty acid-activated proton re-uptake dissipating the proton electrochemical gradient built up by respiration. The present study provides the first evidence that UCP c...

journal_title：FEBS letters

authors： Jarmuszkiewicz W,Antos N,Swida A,Czarna M,Sluse FE

更新日期：2004-07-02 00:00:00