Abstract:
:Using crude membrane preparations of Saccharomyces cerevisiae, we have demonstrated that glucose and glucose analogues which are not efficiently phosphorylated activate the guanine nucleotide-dependent adenylate cyclase in vitro. The activation appears to be mediated by the Ras proteins. Moreover, data are presented indicating that glucose and its analogues activate adenylate cyclase by stimulating the exchange of guanine nucleotides at its regulatory component. Thus, it has been possible to show the action of a physiological effector on the nucleotide exchange reaction in a member of the ras superfamily.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pardo LA,Sánchez LM,Lazo PS,Ramos Sdoi
10.1016/0014-5793(91)81221-ssubject
Has Abstractpub_date
1991-09-23 00:00:00pages
43-8issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(91)81221-Sjournal_volume
290pub_type
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