Abstract:
:Recent studies show LDL receptor-related protein 1B, LRP1B as a transducer of extracellular signals. Here, we identify six interacting partners of the LRP1B cytoplasmic region by yeast two-hybrid screen and confirmed their in vivo binding by immunoprecipitation. One of the partners, PICK1 recognizes the C-terminus of LRP1B and LRP1. The cytoplasmic domains of LRP1B are phosphorylated by PKCalpha about 100 times more efficiently than LRP1. Binding of PICK1 inhibits phosphorylation of LRP1B, but does not affect LRP1 phosphorylation. This study presents the possibility that LRP1B participates in signal transduction which PICK1 may regulate by inhibiting PKCalpha phosphorylation of LRP1B.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Shiroshima T,Oka C,Kawaichi Mdoi
10.1016/j.febslet.2008.11.045subject
Has Abstractpub_date
2009-01-05 00:00:00pages
43-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00961-7journal_volume
583pub_type
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