Abstract:
:The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modifier proteins, Murine double minute (Mdm2) and Small Ubquitin-like MOdifier protein 1 (SUMO-1) in cortical neurons. Delta(9)-THC increased both Mdm2 and SUMO-1 protein expression and induced the deSUMOylation of p53 in a cannabinoid receptor type 1 (CB(1))-receptor dependent manner. We demonstrate that Delta(9)-THC decreased the SUMOylation of the CB(1) receptor. The data reveal a novel role for cannabinoid receptor activation in modulating the SUMO regulatory system.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gowran A,Murphy CE,Campbell VAdoi
10.1016/j.febslet.2009.09.056subject
Has Abstractpub_date
2009-11-03 00:00:00pages
3412-8issue
21eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00778-9journal_volume
583pub_type
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