Abstract:
:The inhibition of electron transport by unnatural (-)-antimycin A3 was examined with rat liver mitochondria and compared with that of natural (+)-antimycin A3. (-)-Antimycin A3 inhibited respiration about 1/100th as strongly as natural (+)-antimycin A3. (-)-Antimycin A3 binding to the cytochrome bc1 complex did not seem to induce a conformational change in this proteinous complex. The binding site of (-)-antimycin A3 was probably the same as that of (+)-antimycin A3 (at the Qi center). However, the mode of interaction with the Qi center by (-)-antimycin A3 and (+)-antimycin A3 was somewhat different.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miyoshi H,Kondo H,Oritani T,Saitoh I,Iwamura Hdoi
10.1016/0014-5793(91)80834-psubject
Has Abstractpub_date
1991-11-04 00:00:00pages
61-3issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80834-Pjournal_volume
292pub_type
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