Abstract:
:This paper summarizes results of the 40-year studies on replication and recombination of RNA molecules in the cell-free amplification system of bacteriophage Q. Special attention is paid to the molecular colony technique that has provided for the discovery of the nature of "spontaneous" RNA synthesis by Q replicase and of the ability of RNA molecules to spontaneously rearrange their sequences under physiological conditions. Also discussed is the impact of these data on the concept of RNA World and on the development of new in vitro cloning and diagnostic tools.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Chetverin ABdoi
10.1016/j.febslet.2004.03.066keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
35-41issue
1eissn
0014-5793issn
1873-3468pii
S0014579304003631journal_volume
567pub_type
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