Abstract:
:Uptake of taurine in human placental brush-border membrane vesicles was greatly stimulated in the presence of an inwardly-directed Na+ + Cl- -gradient and uphill transport of taurine could be demonstrated under these conditions. Na+ as well as Cl- were obligatory for this uptake and both ion gradients could energize the uphill transport. This Na+ + Cl- -gradient-dependent taurine uptake was stimulated by an inside-negative membrane potential, demonstrating the electrogenicity of the process. The uptake system was highly specific for beta-amino acids and the Km of the system for taurine was 6.5 +/- 0.4 microM.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miyamoto Y,Balkovetz DF,Leibach FH,Mahesh VB,Ganapathy Vdoi
10.1016/0014-5793(88)80744-0subject
Has Abstractpub_date
1988-04-11 00:00:00pages
263-7issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(88)80744-0journal_volume
231pub_type
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