Abstract:
:Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Behrensdorf HA,van de Craen M,Knies UE,Vandenabeele P,Clauss Mdoi
10.1016/s0014-5793(99)01777-9keywords:
subject
Has Abstractpub_date
2000-01-21 00:00:00pages
143-7issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(99)01777-9journal_volume
466pub_type
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