Abstract:
:Muscarinic K+ channels (IK(ACh)) in native atrial myocytes are activated by betagamma subunits of pertussis toxin (Ptx)-sensitive heterotrimeric G proteins coupled to different receptors. betagamma subunits of Ptx-insensitive Gs, coupled to beta-adrenergic receptors, do not activate native IK(ACh). In atrial myocytes from adult rats transfected with rat brain beta1 subunit IK(ACh) can be activated by stimulation of beta-adrenergic receptors using isoprenaline. This effect is insensitive to Ptx. These findings demonstrate for the first time promiscuous (Ptx-insensitive) coupling of Gsbetagamma to GIRK channels in their native environment.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bender K,Wellner-Kienitz MC,Meyer T,Pott Ldoi
10.1016/s0014-5793(98)01350-7subject
Has Abstractpub_date
1998-11-13 00:00:00pages
115-20issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01350-7journal_volume
439pub_type
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