Abstract:
:Epichloë festucae Fl1 in association with Lolium perenne synthesizes a diverse range of indole-diterpene bioprotective metabolites, including lolitrem B, a potent tremorgen. The ltm genes responsible for the synthesis of these metabolites are organized in three clusters at a single sub-telomeric locus in the genome of E. festucae. Here we resolve the genetic basis for the remarkable indole-diterpene diversity observed in planta by analyzing products that accumulate in associations containing ltm deletion mutants of E. festucae and in cells of Penicillium paxilli containing copies of these genes under the control of a P. paxilli biosynthetic gene promoter. We propose a biosynthetic scheme to account for this metabolic diversity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Saikia S,Takemoto D,Tapper BA,Lane GA,Fraser K,Scott Bdoi
10.1016/j.febslet.2012.06.035subject
Has Abstractpub_date
2012-07-30 00:00:00pages
2563-9issue
16eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00524-8journal_volume
586pub_type
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