Abstract:
:When rat pancreatic islets were incubated with 10(-8) M arginine vasopressin in the presence of 15 mM glucose there was a pronounced inhibition of insulin release in comparison with controls. This inhibitory effect appeared to be specific for vasopressin since it was antagonised by vasopressin antibody. Moreover, pertussis toxin (100 ng/ml) reversed the inhibition of insulin release due to vasopressin, indicating the possible involvement of a guanyl-nucleotide regulatory protein in the inhibitory effect. Nevertheless, 10(-8) M vasopressin increased islet concentrations of cyclic AMP even under conditions where insulin release was decreased.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Khalaf LJ,Taylor KWdoi
10.1016/0014-5793(88)80720-8subject
Has Abstractpub_date
1988-04-11 00:00:00pages
148-50issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(88)80720-8journal_volume
231pub_type
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