Abstract:
:A double-blinded, placebo-controlled cross-over trial was carried out with 27 hypercholesterolemic men with coronary heart disease. During the 6-week treatment period lovastatin (60 mg/day) decreased fasting serum LDL cholesterol by 45%, LDL phosphorus by 38% and apoB by 33%. Ubiquinol content diminished by 13% as measured per LDL phosphorus. When LDL was oxidized ex vivo with AMVN both LDL ubiquinol and alpha-tocopherol were exhausted faster after lovastatin treatment compared to placebo, by 24% (P < 0.005) and 36% (P < 0.0001), respectively. Lag time in copper-induced oxidation of LDL decreased by 7% (P < 0.01). This suggests diminished antioxidant-dependent resistance of LDL to the early phase of oxidative stress.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Palomäki A,Malminiemi K,Metsä-Ketelä Tdoi
10.1016/s0014-5793(97)00609-1subject
Has Abstractpub_date
1997-06-30 00:00:00pages
254-8issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00609-1journal_volume
410pub_type
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