Abstract:
:The heterogeneity of computationally predicted reaction fluxes in metabolic networks within a single flux state can be exploited to detect their significant flux backbone. Here, we disclose the backbone of Escherichia coli, and compare it with the backbones of other bacteria. We find that, in general, the core of the backbones is mainly composed of reactions in energy metabolism corresponding to ancient pathways. In E. coli, the synthesis of nucleotides and the metabolism of lipids form smaller cores which rely critically on energy metabolism. Moreover, the consideration of different media leads to the identification of pathways sensitive to environmental changes. The metabolic backbone of an organism is thus useful to trace simultaneously both its evolution and adaptation fingerprints.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Güell O,Sagués F,Serrano MÁdoi
10.1002/1873-3468.12650subject
Has Abstractpub_date
2017-05-01 00:00:00pages
1437-1451issue
10eissn
0014-5793issn
1873-3468journal_volume
591pub_type
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