Abstract:
:Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both Smad4 and receptor-associated Smads that regulates their function without protein degradation. Monoubiquitylation of Smads was discovered following the identification of deubiquitylases required for TGF-β signaling, suggesting that continuous cycles of Smad mono- and deubiquitylation are required for proper TGF-β signal transduction. Here we summarize and discuss recent work on Smad mono- and deubiquitylation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Dupont S,Inui M,Newfeld SJdoi
10.1016/j.febslet.2012.03.037subject
Has Abstractpub_date
2012-07-04 00:00:00pages
1913-20issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00237-2journal_volume
586pub_type
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