Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.

Abstract:

:The contributions of membrane type-1 matrix metalloproteinase (MT1-MMP) and of the glucose-6-phosphate transporter (G6PT) in sphingosine-1-phosphate (S1P)-mediated Ca(2+) mobilization were assessed in glioblastoma cells. We show that gene silencing of MT1-MMP or G6PT decreased the extent of S1P-induced Ca(2+) mobilization, chemotaxis, and extracellular signal-related kinase phosphorylation. Chlorogenic acid and (-)-epigallocatechin-3-gallate, two diet-derived inhibitors of G6PT and of MT1-MMP, respectively, reduced S1P-mediated Ca(2+) mobilization. An intact MT1-MMP/G6PT signaling axis is thus required for efficient Ca(2+) mobilization in response to bioactive lipids such as S1P. Targeted inhibition of either MT1-MMP or G6PT may lead to reduced infiltrative and invasive properties of brain tumor cells.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Fortier S,Labelle D,Sina A,Moreau R,Annabi B

doi

10.1016/j.febslet.2008.01.061

subject

Has Abstract

pub_date

2008-03-05 00:00:00

pages

799-804

issue

5

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(08)00101-4

journal_volume

582

pub_type

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