Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1.


:MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/oncogenic long non-coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic down-regulated, whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa-miR-125b and SIRT7/MALAT1. Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up-regulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.




FEBS letters


Han Y,Liu Y,Zhang H,Wang T,Diao R,Jiang Z,Gui Y,Cai Z


Has Abstract


2013-11-29 00:00:00












  • 5'-Nucleotidase is activated upon cholesterol-depletion of liver plasma membranes.

    abstract::The cholesterol content of rat liver plasma membranes was manipulated using either cholesterol-free or cholesterol-enriched liposomes. Removal of cholesterol from the membranes led to a marked increase in 5'-nucleotidase activity. However, increase in cholesterol content failed to exert any significant effect on 5'-nu...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Whetton AD,Houslay MD

    更新日期:1983-06-27 00:00:00

  • ATP potentiates the formation of AChR aggregate in the co-culture of NG108-15 cells with C2C12 myotubes.

    abstract::The role of adenosine 5'-triphosphate (ATP) and P2Y(1) nucleotide receptor in potentiating agrin-induced acetylcholine receptor (AChR) aggregation is being demonstrated in a co-culture system of NG108-15 cell, a mouse neuroblastoma X rat glioma hybrid cell line that resembles spinal motor neuron, with C2C12 myotube. I...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ling KK,Siow NL,Choi RC,Tsim KW

    更新日期:2005-04-25 00:00:00

  • Comparing the temperature dependence of FMN to heme electron transfer in full length and truncated inducible nitric oxide synthase proteins.

    abstract::The FMN-heme interdomain (intraprotein) electron transfer (IET) kinetics in full length and oxygenase/FMN (oxyFMN) construct of human iNOS were determined by laser flash photolysis over the temperature range from 283 to 304K. An appreciable increase in the rate constant value was observed with an increase in the tempe...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Li W,Chen L,Fan W,Feng C

    更新日期:2012-01-20 00:00:00

  • Lipid droplets: a dynamic organelle moves into focus.

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Beller M,Thiel K,Thul PJ,Jäckle H

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  • Arp3 is required during preimplantation development of the mouse embryo.

    abstract::The role of Arp3 in mouse development was investigated utilizing a gene trap mutation in the Arp3 gene. Heterozygous Arp3(WT/GT) mice are normal, however, homozygous Arp3(GT/GT) embryos die at blastocyst stage. Earlier embryonic stages appear unaffected by the mutation, probably due to maternal Arp3 protein. Mutant bl...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Vauti F,Prochnow BR,Freese E,Ramasamy SK,Ruiz P,Arnold HH

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  • Antigenic cross-reactivity between electrolectins.

    abstract::The antigenic cross-reactivity between purified chick, eel and mouse electrolectins (endogenous beta-D-galactoside specific lectins) have been studied using a solid phase radioimmunoassay. The immune serum raised against the eel electrolectin crossreacts both with the chick and the mouse electrolectins, while the anti...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Levi G,Teichberg VI

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  • BIT, an immune antigen receptor-like molecule in the brain.

    abstract::We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containi...

    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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  • Inactivation of tissue inhibitor of metalloproteinase-1 by peroxynitrite.

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    更新日期:1996-02-26 00:00:00

  • The induction of adipose conversion in 3T3-L1 cells is associated with early phosphorylation of a 60-kDa nuclear protein.

    abstract::The induction of adipose conversion in 3T3-L1 cells by bezafibrate has been shown to be enhanced by dibutyryl-cAMP. We here report that the induction of adipose conversion in 3T3-L1 cells, by either bezafibrate and dibutyryl cAMP, or isobutylmethyxanthine alone, is associated with a very early phosphorylation of a 60-...

    journal_title:FEBS letters

    pub_type: 杂志文章


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  • Replicable and recombinogenic RNAs.

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Chetverin AB

    更新日期:2004-06-01 00:00:00

  • High-field (94-GHz) EPR spectroscopy on the S(2) multiline signal of Photosystem II.

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    更新日期:2006-06-26 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    更新日期:1984-10-01 00:00:00

  • Low-energy Mg2+-induced temperature transitions in liver microsomes.

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Goligorsky MS

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  • Systematic screening of LNA/2'-O-methyl chimeric derivatives of a TAR RNA aptamer.

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    更新日期:2007-02-20 00:00:00

  • Developmental regulation of five subunit specific mRNAs encoding acetylcholine receptor subtypes in rat muscle.

    abstract::The muscular content of the mRNAs encoding the five subunits of the nicotonic acetylcholine receptor was measured during postnatal development in the rat. Subunit specific mRNAs show differential regulation. The levels of the alpha-, gamma- and delta-subunit specific mRNAs decrease steadily after birth, while the beta...

    journal_title:FEBS letters

    pub_type: 杂志文章


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    更新日期:1989-01-02 00:00:00

  • The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet-derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein-tyrosine phosphatases.

    abstract::Comparison of the phosphotyrosine-specific dephosphorylation of the autophosphorylated receptors for epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) in Swiss 3T3 cell membranes by the endogenous phosphatases revealed striking differences. EGF receptor dephosphorylation was clearly faster than P...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Böhmer FD,Böhmer SA,Heldin CH

    更新日期:1993-10-04 00:00:00

  • Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.

    abstract::Pleckstrin homology (PH) domains are protein modules found in proteins involved in many cellular processes. The majority of PH domain-containing proteins require membrane association for their function. It has been shown that most PH domains interact directly with the cell membrane by binding to phosphoinositides with...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Maffucci T,Falasca M

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  • Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: D'Archivio M,Scazzocchio B,Filesi C,Varì R,Maggiorella MT,Sernicola L,Santangelo C,Giovannini C,Masella R

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  • Inhibitory effect of acidic pH on OmpC porin: wild-type and mutant studies.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Liu N,Delcour AH

    更新日期:1998-08-28 00:00:00

  • Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes.

    abstract::Increases in choline containing metabolites have been associated with a number of disorders, including malignant cell growth. In this study, high resolution magic angle spinning (1)H nuclear magnetic resonance spectroscopy was employed to monitor metabolite changes during cell transfection, and an increase in phosphoc...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Griffin JL,Mann CJ,Scott J,Shoulders CC,Nicholson JK

    更新日期:2001-12-07 00:00:00

  • Evidence from peptide mapping for a human renin zymogen.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: McIntyre GD,Chaudhuri S,Coggins JR

    更新日期:1984-10-01 00:00:00

  • A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kang J,Jeong MG,Oh S,Jang EJ,Kim HK,Hwang ES

    更新日期:2014-01-03 00:00:00

  • The molecular signature of oncofusion proteins in acute myeloid leukemia.

    abstract::Acute myeloid leukemia (AML) associated translocations often cause gene fusions that encode oncofusion proteins. Although many of the breakpoints involved in chromosomal translocations have been cloned, in most cases the role of the chimeric proteins in tumorigenesis is not elucidated. Here we will discuss the fusion ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Martens JH,Stunnenberg HG

    更新日期:2010-06-18 00:00:00

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    abstract::Incubation of rat skeletal muscle mitochondria with the nitric oxide generator, S-nitrosoglutathione (GSNO) reversibly inhibited oxygen utilisation with all substrates tested. The visible absorption spectra of the inhibited mitochondria showed that cytochromes c+c1, b and a+a3 were reduced, indicating a block at the d...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Cleeter MW,Cooper JM,Darley-Usmar VM,Moncada S,Schapira AH

    更新日期:1994-05-23 00:00:00

  • Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade.

    abstract::Hypo-osmotic swelling of human Intestine 407 cells leads to a significant increase of intracellular MAPKAP-kinase 2 activity and Hsp27 phosphorylation. Pre-treatment of the cells with the p38 MAP kinase inhibitor SB-203580 blocks this activation, indicating that the hypotonicity-induced activation of MAPKAP kinase 2 i...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Tilly BC,Gaestel M,Engel K,Edixhoven MJ,de Jonge HR

    更新日期:1996-10-21 00:00:00

  • Investigation of cytokinin-deficient phenotypes in Arabidopsis by ectopic expression of orchid DSCKX1.

    abstract::The plant hormone cytokinin plays a major role in regulating plant growth and development. Here we generated cytokinin-reduction Arabidopsis plants by overexpressing a heterologous cytokinin oxidase gene DSCKX1 from Dendrobium orchid. These transgenic plants exhibited reduced biomass, rapid root growth, decreased abil...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yang S,Yu H,Xu Y,Goh CJ

    更新日期:2003-12-04 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kee HJ,Park S,Kwon JS,Choe N,Ahn Y,Kook H,Jeong MH

    更新日期:2013-08-02 00:00:00