Abstract:
:The Surfeit locus is an unusual cluster of at least 6 housekeeping genes whose organisation is conserved between birds and mammals. We have previously shown that the divergently transcribed Surf-1 and Surf-2 genes are separated by a bi-directional, TATA-less promoter. In mouse, the Surf-1/Surf-2 promoter contains three important factor binding sites: Su1, Su2, and Su3. These sites are conserved between the mouse and human Surf-1/Surf-2 promoters, bind nuclear factors in vitro, and are required for accurate and efficient expression of Surf-1 and Surf-2 in vivo. Using gel retardation assays, methylation interference experiments, and specific antibodies we demonstrate that the Su1 binding factor is the initiator protein YY1. Over-expression of YY1 results in a major stimulation of transcription in the Surf-1 direction and a minor stimulation of transcription in the Surf-2 direction.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gaston K,Fried Mdoi
10.1016/0014-5793(94)00567-2subject
Has Abstractpub_date
1994-06-27 00:00:00pages
289-94issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(94)00567-2journal_volume
347pub_type
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