Abstract:
:The inhibitor of gamma-glutamyl transpeptidase (gamma-GT) acivicin modulates cellular responses including growth, myeloid maturation and apoptosis. Whether these effects result from the inhibition of gamma-GT enzyme activity remains unclear. We compared the cellular effects of acivicin against a more potent and specific inhibitor of gamma-GT (L-2-amino-4-boronobutanoic acid (L-ABBA)) in gamma-GT-negative (B lymphoblastoid Ramos) and gamma-GT-positive (myelomonocytic HL-60, gamma-GT-transfected Ramos) cell lines. Under non-oxidative stress conditions, acivicin-induced cell growth arrest, apoptosis and macrophage maturation occurred independent of gamma-GT while L-ABBA did not influence any of these processes. Acivicin triggered tyrosine phosphorylation and increased nuclear factor kappaB activity. Further insight into the role of gamma-GT in cellular processes is needed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Antczak C,Karp DR,London RE,Bauvois Bdoi
10.1016/s0014-5793(01)03057-5keywords:
subject
Has Abstractpub_date
2001-11-16 00:00:00pages
226-30issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(01)03057-5journal_volume
508pub_type
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