Abstract:
:As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that down-regulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yang F,Yi F,Han X,Du Q,Liang Zdoi
10.1016/j.febslet.2013.07.048subject
Has Abstractpub_date
2013-10-01 00:00:00pages
3175-81issue
19eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00610-8journal_volume
587pub_type
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