Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model.

Abstract:

:Rats bearing the Yoshida AH-130 ascites hepatoma showed an increased expression of both uncoupling protein-2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation. Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair-fed animals, suggesting that the increase in gene expression was the result of the anorexia associated with tumour burden. The results constitute the first report of UCP2 and UCP3 gene expression during cancer cachexia and agree to their possible role in the increase of energy expenditure associated with tumour growth.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Sanchís D,Busquets S,Alvarez B,Ricquier D,López-Soriano FJ,Argilés JM

doi

10.1016/s0014-5793(98)01178-8

subject

Has Abstract

pub_date

1998-10-09 00:00:00

pages

415-8

issue

3

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(98)01178-8

journal_volume

436

pub_type

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