Abstract:
:Rats bearing the Yoshida AH-130 ascites hepatoma showed an increased expression of both uncoupling protein-2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation. Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair-fed animals, suggesting that the increase in gene expression was the result of the anorexia associated with tumour burden. The results constitute the first report of UCP2 and UCP3 gene expression during cancer cachexia and agree to their possible role in the increase of energy expenditure associated with tumour growth.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sanchís D,Busquets S,Alvarez B,Ricquier D,López-Soriano FJ,Argilés JMdoi
10.1016/s0014-5793(98)01178-8subject
Has Abstractpub_date
1998-10-09 00:00:00pages
415-8issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01178-8journal_volume
436pub_type
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