Abstract:
:Amylin, a 37 amino acid C-terminal amidated peptide is an integral part of secretory granules of pancreatic beta-cells. Utilizing a specific radioimmunoassay system we demonstrate in the present study a cosecretion of amylin and insulin from the isolated rat pancreas. The secretion pattern of both peptides during glucose or glucose plus arginine stimulation is identical. The molar ratio of amylin amounts to 10% of that of insulin. The biological significance of amylin is still unknown, but a paracrine/endocrine role in glucose homeostasis is speculated.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fehmann HC,Weber V,Göke R,Göke B,Arnold Rdoi
10.1016/0014-5793(90)80210-asubject
Has Abstractpub_date
1990-03-26 00:00:00pages
279-81issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80210-Ajournal_volume
262pub_type
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