Abstract:
:Polymyxin B (PXB), a cyclic peptide antibiotic, in concentrations 0.1-3.0 mg/ml (0.08-4.0 mmol/l), inhibited the K+ efflux induced by opening of the Ca2+-activated K+ channel (the Gárdos effect) in intact human red blood cells. The inhibition was observed when the Gárdos effect was elicited by Ca2+ in the presence of vanadate, or propranolol, in ATP-depleted cells, and in A23187-treated cells. The inhibition of the Gárdos effect is caused neither by the inhibition of the anion channel by PXB nor by the inhibition of Ca2+ entry. It can be ascribed to the inhibition of the Ca2+-activated K+ channel. The mechanism of the inhibition remains to be elucidated.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Varecka L,Peterajová E,Pogády Jdoi
10.1016/0014-5793(87)81152-3subject
Has Abstractpub_date
1987-12-10 00:00:00pages
173-7issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(87)81152-3journal_volume
225pub_type
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