Abstract:
:We have found that N-acetylneuraminic acid (NANA) consumes toxic hydrogen peroxide (H(2)O(2)) under physiological conditions. Close investigation of this finding revealed that NANA was oxidized by an equimolar amount of H(2)O(2) to provide its decarboxylated product, 4-(acetylamino)-2,4-dideoxy-D-glycero-D-galacto-octonic acid (ADOA). To date, there have been little data on this reaction, and its physiological significance has not been discussed. Examining the detoxification of H(2)O(2) in cultured cells with NANA, we were able to confirm that the cell death caused by H(2)O(2) was suppressed by NANA in a dose-dependent manner. These results revealed a novel role for NANA as a reactive oxygen scavenger. It is known that terminal NANA residues are removed by neuraminidase and that free NANA molecules are recycled or degraded by enzymes. We propose that released monomeric NANA is the potent defense molecule against oxidative damage.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Iijima R,Takahashi H,Namme R,Ikegami S,Yamazaki Mdoi
10.1016/S0014-5793(04)00164-4keywords:
subject
Has Abstractpub_date
2004-03-12 00:00:00pages
163-6issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579304001644journal_volume
561pub_type
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