Abstract:
:Several lines of evidence led to the conclusion that mammalian ribosomal protein synthesis is a highly organized biological process in vivo. A wealth of data support the concept according to which tRNA aminoacylation, formation of the ternary complex on EF1A and delivery of aminoacyl-tRNA to the ribosome is a processive mechanism where tRNA is vectorially transferred from one component to another. Polypeptide extensions, referred to as tRBDs (tRNA binding domains), are appended to mammalian and yeast aminoacyl-tRNA synthetases. The involvement of these domains in the capture of deacylated tRNA and in the sequestration of aminoacylated tRNA, suggests that cycling of tRNA in translation is mediated by the processivity of the consecutive steps. The possible origin of the tRBDs is discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mirande Mdoi
10.1016/j.febslet.2009.11.027subject
Has Abstractpub_date
2010-01-21 00:00:00pages
443-7issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00929-6journal_volume
584pub_type
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