COP9 signalosome function in the DDR.

Abstract:

:The COP9 signalosome (CSN) is a platform for protein communication in eukaryotic cells. It has an intrinsic metalloprotease that removes the ubiquitin (Ub)-like protein Nedd8 from cullins. CSN-mediated deneddylation regulates culling-RING Ub ligases (CRLs) and controls ubiquitination of proteins involved in DNA damage response (DDR). CSN forms complexes with CRLs containing cullin 4 (CRL4s) which act on chromatin playing crucial roles in DNA repair, checkpoint control and chromatin remodeling. Furthermore, via associated kinases the CSN controls the stability of DDR effectors such as p53 and p27 and thereby the DDR outcome. DDR is a protection against cancer and deregulation of CSN function causes cancer making it an attractive pharmacological target. Here we review current knowledge on CSN function in DDR.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Hannss R,Dubiel W

doi

10.1016/j.febslet.2011.04.027

subject

Has Abstract

pub_date

2011-09-16 00:00:00

pages

2845-52

issue

18

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(11)00274-2

journal_volume

585

pub_type

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