Abstract:
:The KDEL receptor is a seven-transmembrane-domain protein that was first described about 20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone-bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi-to-plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Capitani M,Sallese Mdoi
10.1016/j.febslet.2009.10.053subject
Has Abstractpub_date
2009-12-03 00:00:00pages
3863-71issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00841-2journal_volume
583pub_type
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