Abstract:
:The metabolism of 20:4 (arachidonic acid) in alkenylacyl, alkylacyl and diacyl lipid classes in choline glycerophospholipids (CGP) and ethanolamine glycerophospholipids (EGP) in rabbit alveolar macrophages was examined. [3H]20:4 was very rapidly incorporated into diacyl glycerophosphocholine (GPC). After the removal of free 20:4, the radioactivity was gradually lost from diacyl GPC. Concomitantly, the radioactivities in alkylacyl GPC and alkenylacyl glycerophosphoethanolamine (GPE) were increased, indicating that 20:4 was mobilized from diacyl GPC to alkylacyl GPC and alkenylacyl GPE. The mobilization was considered to be a 20:4-specific event. The gradual accumulation of 20:4 in ether phospholipids leads to a high abundance of 20:4 in these lipids. These results suggest metabolic relationships between 20:4 and ether phospholipids, including platelet-activating factor (PAF).
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sugiura T,Katayama O,Fukui J,Nakagawa Y,Waku Kdoi
10.1016/0014-5793(84)80184-2subject
Has Abstractpub_date
1984-01-09 00:00:00pages
273-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(84)80184-2journal_volume
165pub_type
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