Abstract:
:The usefulness of a gamma camera system for external imaging of the degradation sites of low-density lipoprotein (LDL) is demonstrated in rats. [131I]LDL was injected intravenously in normal rats and rats pretreated with 17 alpha-ethinyl estradiol for LDL receptor induction. Distribution of the radioligand was followed for 20 min, for perfusion control [131I]albumin was administered. Rats pretreated with 17 alpha-ethinyl estradiol showed a marked increase in the LDL uptake by the liver, which was not competed by the preinjection of physiological amounts of unlabelled LDL. It is concluded that the injection of small amounts of [131I]LDL is sufficient to image the hepatic LDL receptor and that the endogenous LDL does not compete effectively at physiological LDL levels.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Friedrich E,Dresel HA,Sinn H,Schettler Gdoi
10.1016/0014-5793(85)80669-4subject
Has Abstractpub_date
1985-05-06 00:00:00pages
134-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(85)80669-4journal_volume
184pub_type
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