Abstract:
:This paper describes a mechanism of coupling periodate-oxidized nucleosides to proteins. Each of the dialdehyde groups of a periodate-oxidized nucleoside is shown to couple to lysine residues on different protein molecules through Schiff bases, thereby cross-linking different protein molecules, forming a polymer. This is in contrast to the previous model in which nucleosides were suggested to couple to proteins through a morpholine structure. The cross-linked structure of the nucleoside-antigen, significantly different when compared to the native protein, may affect the specificity and the efficiency of antibody production.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Senapathy P,Ali MA,Jacob MTdoi
10.1016/0014-5793(85)81314-4subject
Has Abstractpub_date
1985-10-14 00:00:00pages
337-41issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)81314-4journal_volume
190pub_type
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