Transforming growth factor alpha protects against Fas-mediated liver apoptosis in mice.

Abstract:

:The Fas/Fas ligand interaction plays a crucial role in various liver diseases, and administration of agonistic anti-Fas antibody to mice causes massive hepatic apoptosis and fulminant hepatic failure. Several growth factors have recently been found to function in preventing apoptosis. In this study, we demonstrated that overexpression of transforming growth factor alpha (TGFalpha) has a dramatic protective effect on Fas-mediated hepatic apoptosis at the biochemical and histological levels. Moreover, 85.7% (six out of seven) of TGFalpha transgenic mice survived the lethal liver damage, whereas all wild-type mice died. Expression of Bcl-xL, an anti-apoptotic protein, was greatly increased in the transgenic mice. Taken together, our findings suggest that TGFalpha protects against Fas-mediated liver apoptosis in vivo and up-regulation of Bcl-xL may participate in protective effect of TGFalpha.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Kanda D,Takagi H,Toyoda M,Horiguchi N,Nakajima H,Otsuka T,Mori M

doi

10.1016/s0014-5793(02)02677-7

keywords:

subject

Has Abstract

pub_date

2002-05-22 00:00:00

pages

11-5

issue

1-3

eissn

0014-5793

issn

1873-3468

pii

S0014579302026777

journal_volume

519

pub_type

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