Abstract:
:We studied the effect of high-fat diet on the expression and activation of the three caveolins in rat skeletal muscle and their association with the insulin signalling cascade. Initial response was characterized by increased signalling through Cav-1 and Cav-3 phosphorylation, suggesting that both participate in an initial acute response to the calorie surplus. Afterwards, Cav-1 signalling was slightly reduced, whereas Cav-3 remained active. Late chronic phase signalling through both proteins was impaired inducing a prediabetic state. Summarizing, caveolins seem to mediate a time-dependent regulation of insulin cascade in response to high-fat diet in muscle.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gómez-Ruiz A,de Miguel C,Campión J,Martínez JA,Milagro FIdoi
10.1016/j.febslet.2009.09.016subject
Has Abstractpub_date
2009-10-06 00:00:00pages
3259-64issue
19eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00704-2journal_volume
583pub_type
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