Abstract:
:The activity of calcium, phospholipid-dependent protein kinase (PKc), which is thought to play an important role in cell proliferation, has been measured in the particulate and soluble fractions of cultured cells, under different proliferative conditions. Our results indicate that proliferating cells display higher PKc activity than quiescent cells. Furthermore, in both normal and transformed cells, PKc is preferentially associated with the particulate fraction when the cells are proliferating, while in mitotically quiescent cells the majority of the enzyme activity is found in the soluble fraction. These data suggest tha PKc activity and subcellular distribution undergo spontaneous changes according to the proliferative state of the cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Adamo S,Caporale C,Aguanno S,Lazdins J,Faggioni A,Belli L,Cortesi E,Nervi C,Gastaldi R,Molinaro Mdoi
10.1016/0014-5793(86)80192-2subject
Has Abstractpub_date
1986-01-20 00:00:00pages
352-6issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(86)80192-2journal_volume
195pub_type
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