Abstract:
:The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Brosh R,Sarig R,Natan EB,Molchadsky A,Madar S,Bornstein C,Buganim Y,Shapira T,Goldfinger N,Paus R,Rotter Vdoi
10.1016/j.febslet.2010.04.058subject
Has Abstractpub_date
2010-06-03 00:00:00pages
2473-7issue
11eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00343-1journal_volume
584pub_type
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